What is Mushroom Beta Glucan?
For centuries, mushrooms have been valued for their medicinal properties and health benefits. Beta-glucan, which primarily consists of beta-D-glucose and is found in the fungal cell wall, is one of the unique components that mushrooms contain. In numerous studies, beta-glucan effectively stimulates the immune system of the host to protect against parasitic, bacterial, viral, or fungal infections. Additionally, due to the fact that it primarily affects the host immune system, it is referred to as a biological response modifier. By binding to the receptor (dectin-1) of macrophages, neutrophils, and natural killer (NK) cells, beta-glucan shows that it stimulates these cells and alters the systems.
Mushroom beta-glucan is a carbohydrate polymer derived from the cell walls of mushrooms. Research shows that this unique polymer effectively supports the body's natural defense mechanisms by activating frontline immune cells to support a healthy and robust immune response without overstimulation. Beta-glucans are known as biological response modifiers (BRMs), which refer to the ability to up-regulate and down-regulate the responses of biological systems. Clinical research results show that the presence of β-glucan is related to the production and activation of macrophages, NK cells, T cells and B cells in the body's natural defense system. This is achieved through a series of biological reactions triggered by the binding of β-glucan molecules to Dectin-1/CR3 receptors on cells.
What mushroom has beta-glucan?
Beta-glucans are polysaccharides that occur naturally in the cell walls of functional mushrooms, such as Reishi, Turkey Tail, Shiitake, and Maitake, as well as in oats, barley, bacteria, yeast, and algae.
Studies have shown that edible fungi such as Ganoderma lucidum, shiitake mushrooms, Hericium erinaceus, Cordyceps militaris, Grifola frondosa, Chaga, Yunzhi, Agaricus blazei, Tremella, Oyster mushroom, Agaricus bisporus, etc. all contain Beta 1,3/1,6 D Glucan.
Which mushroom has highest in beta-glucan?
The most beta-glucans have been found in Shiitake, maitake, reishi, oyster, and Shiitake varieties, according to studies. The mushrooms work best to raise cholesterol levels and improve how the immune system works.
How to extract beta-glucan from mushroom?
Oyster mushroom beta-glucans are frequently used in dietary supplements. A routine, multi-stage extraction using sequential ethanol and aqueous extraction is one of the traditional methods for extracting these compounds.
Extraction method: water extraction (using compound enzyme method to assist hot water extraction to extract Hericium erinaceus/lentinus edodes β-glucan) At present, the extraction methods of Hericium erinaceus polysaccharides include alkali extraction, acid extraction, salt extraction and so on. There is hot water extraction.
A method for extracting polysaccharides from Hericium erinaceus with good purity. The method includes: adding water to dried Hericium erinaceus powder, extracting with 8-20KHz ultrasonic waves at 50-80°C for 0.5h-2.0h, filtering, and using a sufficient amount of cellulase in the filtrate in turn , hydrolysis with pectinase and papain, finally adding hydrogen peroxide, stirring at 30-50°C for 0.5h-1h, ultrafiltration with ultrafiltration membrane, collecting components with a molecular weight above 10,000 Daltons, freeze-drying to obtain Hericium erinaceus polysaccharide The beneficial effects of the present invention are mainly reflected in: 1. The obtained product has high purity, wherein the content of β-glucan can be as high as more than 40%, and the biological activity is high, and the yield of crude polysaccharide of Hericium erinaceus can reach 12.2%; 2. Hydrogen peroxide is used for decolorization, the conditions are mild, the polysaccharide structure is not easy to be damaged, and the by-product is water, which is green and environmentally friendly and meets the production requirements of health food.
Extract part: fruiting body (spore, mycelium and fruiting body are different stages of its growth, spore is like the seed of a plant, and the hyphae grows after the seed germinates, while the fruiting body is the fruit of Ganoderma lucidum, and the fruiting body is the edible fungus, The main edible and medicinal parts of medicinal fungi)
reishi mushroom beta glucan
Beta-glucans are a type of fiber that are found in the cells of some yeast, algae, bacteria, and fungi, such as reishi mushrooms.
They fall under the category of immunomodulators; essentially, they alter your immune system in order to maximize its effectiveness.
Beta-glucans put the immune cells on "high alert" to fight off foreign pathogens when the body encounters them. Simply put, beta-glucans are the catalyst that boosts the intelligence of our immune systems and our wellness forces.
The FDA only certifies Rowdy Mermaid's reishi beta-glucans as GRAS (generally recognized as safe). They have no taste or smell, but they have a lot of power!
oyster mushroom beta glucan
Oyster mushrooms, also known as Pleurotus ostreatus, are a type of wood fungus with a high nutritional value that are frequently consumed due to their low cost. It contains -glucan [8], a glucose polymer that binds to the -1,3-glucan and -1,6-glucan -glycoside rings.
shiitake mushroom beta-glucan
Polysaccharides with biological activity can be found in the shiitake mushrooms (Lentinula edodes), the majority of which are -glucans. Bacteria, fungi, and yeast have all been found to contain beta-glucan in their cell walls.
chaga mushroom beta glucan
Chaga has been shown to have a lot of beta-glucans, which are thought to help the body fight off a variety of diseases. Chaga's all-natural health benefits can be enjoyed in liquid extracts or dried forms that can be used to make Chaga teas.
turkey tail mushroom beta-glucan
Investigating product development routes and the B-glucan content of cancer patients' turkey tail mushroom extracts.
We will use an independent laboratory with expertise in the analysis of -d-Glucan in order to accomplish the Primary Objective of determining the level of -d-Glucan in variously produced extracts.
The Megazyme method, which uses enzymatic lysis of polysaccharides and spectrophotometric analysis to quantify -glucan to determine the amount of -d-glucan remaining, will serve as the basis for the new approach.
Tests will be carried out in accordance with GxP standards and a Quality Management System, and a comprehensive report on the validation steps taken and adjustments made to remove interference signals from the sample will be produced by the laboratory.
To eliminate any possibility of bias, the Lab will not be aware of where the samples came from.
mushroom beta-glucan cancer
The growth of cancer can be directly inhibited by mushrooms or -glucans. This is something that Chen et al. showed that the mushroom Fomes fomentarius's exopolysaccharide has a dose- and time-dependent direct antiproliferative effect on human gastric cancer cells in vitro (68). Xie and co. demonstrated that Ganoderma lucidum glucan extract inhibits SW480 human colorectal cancer cell proliferation (69). By directly interacting with the colon cancer cells and inducing their apoptosis, we were able to isolate a soluble -glucan from P. ostreatus and demonstrate that this glucan controls the proliferation of colon cancer cells (70).
Human ovarian cancer HRA cells were subjected to apoptosis, or programmed cell death, by a crude-(16)-glucan extract from Agaricus blazei. This appears to involve activation of the p38 MAPK pathway by translocation of an apoptosis activator Bax from the cytosol to the mitochondria, cytochrome c release, and caspase 9 activation, as the apoptotic effect of this -glucan could be eliminated by applying the p38 MAPK-specific inhibitor SB203580.
mushroom beta-glucan covid
The natural polysaccharides known as beta-glucans can be found in a variety of organisms, including microfungi and macrofungi (mushrooms), as well as in bacteria, algae, and plants like cereal seeds. They have anticancer, antibacterial, and antiviral properties, as well as metabolic and immunomodulatory properties. Beta-glucans have been linked to COVID-19 treatment and prevention in recent studies. Mushroom-derived -glucans, in contrast to those from other sources, are distinguished by their 1,3-glucans and their short 1,6-side chains. This design is perceived by receptors situated on the outer layer of invulnerable cells; consequently, mushroom β-glucans have explicit immunomodulatory properties and acquired BRM (natural reaction modifier) status.
The formation of a triple helix conformation, which is one of the main factors influencing mushroom beta-glucans' bioactivity, is also responsible for the properties of mushroom beta-glucans. The most recent research on the biological and health-promoting potential of mushroom beta-glucans for the treatment of civilization and viral diseases, with a focus on COVID-19, is summarized in this review.
mushrooms beta glucans immune system
Our Mushroom Immune with Beta Glucans was developed by our experts to support a healthy immune response. We combine a triple dose of immune-modulating mushrooms, which is equivalent to nearly one and a half fresh servings. In addition, we added a patented beta glucan from Baker's yeast, which has been shown in clinical studies to help the body maintain a healthy immune response.
Therefore, use Mushroom Immune with Beta Glucans to support a well-balanced immune response..
References:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995106/
https://ommushrooms.com/blogs/blog/beta-glucans-benefits
https://cannabotech.com/a/s/community/medicinal-mushrooms/which-medicinal-mushrooms-are-high-in-beta-glucans
https://www.researchgate.net/publication/329916729_Development_of_new_methods_for_isolation_of_mushroom_beta-glucans_for_the_use_in_the_food_industry_and_their_comparative_evaluation
https://rowdymermaid.com/blogs/insights/reishi-derived-beta-glucans
https://aip.scitation.org/doi/pdf/10.1063/1.5115723
https://chichaga.com/the-health-benefits-of-beta-glucans/
https://atm.amegroups.com/article/view/3399/4250
https://pubmed.ncbi.nlm.nih.gov/34836215/
https://www.lifeextension.com/vitamins-supplements/item02426/mushroom-immune-with-beta-glucans